Pharmacology has a cation bias. For too long, research has focused heavily on sodium and potassium channels, often treating anion transport as a secondary ...

Chloride channels, particularly those of the CLC family, are vital for cellular homeostasis by facilitating the exchange of chloride ions and protons across membranes. These transport proteins govern ...

Chloride channels and antiport mechanisms are pivotal for maintaining cellular ion homeostasis and regulating physiological processes such as muscle contraction, epithelial fluid transport and ...

Every year, sepsis kills roughly 11 million people worldwide, more than lung cancer and heart attacks combined. Despite decades of research, no drug exists that directly strengthens the immune ...

A research team has discovered a previously unknown mechanism by which the immune system fights bacterial infections. The scientists found that a specific protein, the chloride channel PACC1, is ...

A tiny antibody component could fundamentally transform the treatment of cystic fibrosis: For the first time, researchers ...